Browsing by Author "Delidakis, Christos"
Now showing items 1-8 of 8
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Ectopic expression of individual E(spl) genes has differential effects on different cell fate decisions and underscores the biphasic requirement for Notch activity in wing margin establishment in Drosophila
Ligoxygakis, P.; Bray, S. J.; Apidianakis, Yiorgos; Delidakis, Christos (1999)A common consequence of Notch signalling in Drosophila is the transcriptional activation of seven Enhancer of split [E(spl)] genes, which encode a family of closely related basic-helix-loop-helix transcriptional repressors. ...
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Article
Groucho mediates a Ci-independent mechanism of hedgehog repression in the anterior wing pouch
Apidianakis, Yiorgos; Grbavec, D.; Stifani, S.; Delidakis, Christos (2001)Groucho (Gro) is the founding member of a family of transcriptional co-repressors that are recruited by a number of different transcription factors. Drosophila has a single gro gene, whose loss of function affects processes ...
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Article
Hedgehog restricts its expression domain in the Drosophila wing
Bejarano, F.; Pérez, L.; Apidianakis, Yiorgos; Delidakis, Christos; Milán, M. (2007)The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein ...
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The interplay between DSL proteins and ubiquitin ligases in Notch signaling
Pitsouli, Chrysoula; Delidakis, Christos (2005)Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was ...
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Article
Neural hyperplasia induced by RNA interference with m4/mα gene activity
Nagel, A. C.; Apidianakis, Yiorgos; Wech, I.; Maier, D.; Delidakis, Christos; Preiss, A. (2000)The E(spl) complex (E(spl)-C) contains three different classes of genes that are downstream of Notch signaling. The bHLH genes mediate the Notch signal by repressing proneural gene activity, for example during the ...
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Neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis
Pavlopoulos, Elias; Pitsouli, Chrysoula; Klueg, K. M.; Muskavitch, M. A. T.; Moschonas, Nicholas K.; Delidakis, Christos (2001)Activation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction. The ligand Dl has been proposed to effect this N-EC shedding ...
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Overexpression of the m4 and mα genes of the E(spl)-Complex antagonizes Notch mediated lateral inhibition
Apidianakis, Yiorgos; Nagel, A. C.; Chalkiadaki, Angeliki; Preiss, A.; Delidakis, Christos (1999)Intercellular signalling mediated by Notch proteins is crucial to many cell fate decisions in metazoans. Its profound effects on cell fate and proliferation require that a complex set of responses involving positive and ...
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Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis
Glittenberg, M.; Pitsouli, Chrysoula; Garvey, C.; Delidakis, Christos; Bray, S. (2006)Notch is the receptor in a signalling pathway that operates in a diverse spectrum of developmental processes. Its ligands (e.g. Serrate) are transmembrane proteins whose signalling competence is regulated by the ...